To investigate the effects of manual cardiopulmonary resuscitation (CPR) and mechanical assisted CPR on ischemic cardiac/cerebral injury in patients with respiratory and cardiac arrest.Methods 108 patients with respiratory and cardiac arrest rescued in the hospital were selected from January 2018 to June 2021. Among them, 52 patients undergoing manual CPR between January 2018 and October 2019 were included in the control group, and 56 patients undergoing mechanical assisted CPR, namely, using a cardiopulmonary resuscitation machine instead of manual compression from November 2019 to June 2021 were included in the study group. Advanced airway was established for mechanical ventilation in both groups. The success rate and duration of CPR were compared between the two groups. Cerebral blood perfusion, arterial partial pressure of oxygen (PaO2), end expiratory carbon dioxide partial pressure (PETCO2), blood oxygen saturation (SaO2), blood pressure, and blood lactate levels of patients with successful CPR after 15 min and 30 min of CPR were compared between the two groups. Results The success rate of CPR in the study group was 30.36%, higher than 13.46% in the control group (P＜0.05), and the duration of CPR was shorter than that of the control group (P＜0.05). After 15 min and 30 min of CPR, the mean cerebral blood flow velocity and mean cerebral blood flow of the study group were higher than those of the control group (P＜0.05). PaO2 and PETCO2 of the study group were higher than those of the control group (P＜0.05). The systolic and diastolic blood pressure and SaO2 of study group were higher than those of the control group (P＜0.05), and the blood lactic acid level was lower than that of the control group (P＜0.05). Conclusion Compared with manual CPR, mechanical assisted CPR can achieve a higher success rate of rescue, faster recovery of cerebral blood perfusion and improvement of hypoxemia, and reduce ischemic cardiac/cerebral injury.