To investigate the effect of impaired controlled recovery on survival prognosis in patients with severe multiple injuries. Methods The clinical data of 412 patients with severe multiple injuries who were treated in the emergency department of our hospital from July 2018 to July 2021 were retrospectively selected for analysis. According to the intervention plan, the patients were divided into a control group and a study group, with 206 cases in each group. Active fluid resuscitation combined with injury control surgery was used in the control group, and injury control resuscitation strategy was used in the study group. Fully automated biochemical analyzer to determine prothrombin time (PT), activated partial P T T time (APTT)), lactate (LA) level, residual base (BE) for 3 months. According to the follow-up results, the patients who died due to severe multiple injuries were regarded as the death group, and the patients who did not die within 3 months were regarded as the survival group, and the survival days of the two groups were observed and counted. Survival analysis was performed by Kaplan-Meier method and Log-rank test was performed, and logistic regression analysis was used for the influencing factors of prognosis and survival. Results The levels of PT, APTT and LA were lower than those in the control group (P＜0.05), The BE levels were higher than those in the control group (P＜0.05); After 3 months of follow-up, A total of 4 people died in 206 patients in the study group, The average survival time was (40.16±5.23) d; Eight patients died in the control group, The average survival time was (30.26±2.06) d, The Logrank analysis chi-square value for both groups was 15.577, The Pvalue is 0.000, The difference was significant (P＜0.05). There were significant differences in the proportion of surviving patients and dead patients with different ages, ISS score, time from injury to treatment, fluid replacement volume, blood transfusion volume,shock or not (P＜0.05). Logistic regression analysis showed that age, ISS score, time from injury to hospital visit, shock, fluid volume, and blood transfusion were independent prognostic factors for the survival of patients with severe multiple injuries (P＜0.05). Conclusion The injury control resuscitation strategy can effectively improve the coagulation function of patients with severe multiple trauma, reduce the disturbance to the patient's internal environment, and improve the prognosis of the patient.