o discuss the clinical features and prognosis of different histopathological types of chronic sinusitis with nasal polyps (CRSwNP).Methods A total of 136 patients with CRSwNP admitted to our hospital from January 2020 to June 2021 were selected. The clinical and pathological data of the patients were collected and divided into eosinophil CRSwNP group (EOS CRSwNP group, n=36) and non acidophilic granulocyte CRSwNP group (NONEOS CRSw NP group, n=100). The clinical features, Lund-Mackay Scale score and prognosis of the two groups were compared.Results Among the 136 patients, 26.5% (36/136) were EOS CRSwNP patients and 73.5% (100/136) were NONEOS CRSwNP patients. There were no statistically significant difference in terms of gender, age, course (P＞0.05). Rate of peripheral blood eosinophilia granulocyte, preoperative VAS score and nasal sinuses end test 22 (SNOT-22) score were significantly higher in EOS CRSwNP group than that of NONEOS CRSw NP (P＜0.05). About two groups of preoperative CT grading system Lund-Kennedy, there was no statistically significant difference (P＞0.05). The scores of anterior ethmoid sinus, posterior ethmoid sinus, sphenoid sinus, and sinooronasal tract complex in EOS CRSwNP group were significantly higher than those in NONEOS CRSwNP group. EOS CRSwNP group of maxillary sinus score was significantly lower than NONEOS CRSw NP group, the differences were statistically significant (P＜0.05). The visual analogue scale (VAS) score of EOS CRSwNP group was significantly higher than that of NONEOS CRSwNP group 12 months after operation. EOS CRSwNP group after 6 months, 12 months Lund-Kennedy endoscopic mucosal morphology score was significantly higher than NONEOS CRSwNP group, the differences were statistically significant (P＜0.05). Postoperative follow up of 12 months, EOS CRSwNP group of recurrent nasal polyps 2 cases, there was no statistically significant difference (P＞0.05).\Conclusion Before surgery, the competent disease score and CT score of CRSw NP patients can help predict the classification, and the prognosis of patients with different classifications is different, and the prognosis of EOS CRSwNP patients is poor.