According to whether the patient complicated with multiple organ dysfunction syndrome after admission within 4 weeks, the 130 elderly patients with multiple injuries were divided into MODS group(n=42) and non MODS group(n=88). Uni variate analysis showed significant difference(P＜0.05) between the two groups in seven clinical parameters, including major injury site, ISS, D-dimer level, lactic acid level in arterial blood, APACHEIII score, whether with emergency surgery and sepsis. However, there was no significant difference(P＞0.05) between the two groups in six clinical parameters, including sex, age, cause of injury, time before admission, number of injury sites and whether with blood transfusion. Multivariate logistic regression analysis indicated that major injury site, ISS, D-dimer level, lactic acid level in arterial blood, APACHEIII score and whether with sepsis were independent risk factors for MODS in elderly patients with multiple injuries in shortterm(P＜0.05). Conclusion The independent risk factors for short-term MODS in elderly patients with multiple injuries included major injury site, ISS, D-dimer level, lactic acid level in arterial blood, APACHEIII score and whether with sepsis. Attention to major injury site, the evaluation of injury severity, coagulation function and comprehensive illness severity, while effective fluid resuscitation,improving microcirculation, maintaining internal environmental stability and preventing infection can reduce the risk of MODS in elderly patients with multiple injuries in shortterm.