he study aimed to evaluate the impact of the warning label “Ejection Fraction (LVEF)＜50%”on the delivery of care to heart failure (HF) patients in non cardiology settings. Methods Non-cardiac inpatients underwent echocardiography from January to June 2018 were prospectively enrolled, with a warning label stating “Ejection Fraction ＜50%”added on echocardiography reports if they had LVEF of ＜50% (Labeled group). A similar group of patients retrospectively recruited from January to June 2017 were as the control group (Unlabeled group). HF-related management during hospitalization collected by hospital information system were compared between the two groups, including the rates of HF diagnosis, N-terminal-pro-B-type natriuretic peptide (NT-proBNP) testing, in-hospital cardiology consultation, referral to a cardiology clinic, prescription of HF guideline directed medical therapy and cardiology clinic visit. All patients were subdivided into HF with mildly-reduced LVEF (40%～50%, HFmrEF) and HF with reduced LVEF (＜40%, HFrEF) within the Labeled and Unlabeled group. Similarly, we subdivided subjects into 'Medical' and 'Surgical' as per their admission specialties and whether they received in-hospital cardiology consultation. Results Com-pared to the unlabeled group, the labeled group had a higher rate of referral to a cardiol-ogy clinic and requests for cardiology consultation. No difference was found in the rate of HF diagnosis, request for NT-proBNP testing, guideline directed medical therapy and cardiology clinic visit. The Labeled group had higher rate of cardiology consultation and referral to a cardiology clinic was significant in HF patients with LVEF 40%～50% (HFmrEF) (P＜0.05), but not in HF patients with LVEF＜40% (HFrEF). By Logistic regression analysis, the Warning Label was independently associated with an increased odds ratio for cardiology consultation (OR=1.45,P=0.02).Conclusion The warning label enhanced the specialist intervention for HF patients treated in non cardiology settings, especially in the patients with mildly reduced LVEF.