Objective To explore the effect of acupoint application of Changtong ointment on gastrointestinal reaction in patients with chronic kidney disease. Methods 95 patients with stage 3-5 chronic kidney disease hospitalized in Department of Nephrology of our hospital from January 2021 to October 2021 were selected as the research subject. They were randomly divided into two groups: the control group (n=47) and the observation group (n=48). The control group was treated with conventional treatment methods, and the observation group was treated with Changtong ointment. After 2 weeks of treatment, the gastrointestinal symptoms, gastrointestinal hormones, renal function analysis of satisfaction and other dimensions were compared. Results Before treatment, there was no statistically significant difference in the scores of gastrointestinal symptom scale (GSRS), serum somatostatin (SS), vasoactive intestinal peptide (VIP), motilin (MOT), creatinine (SCR), urea nitrogen (BUN) and 24-hour urinary protein (24houtp) (P＞0.05). After 2 weeks of intervention, the score of gastrointestinal symptom scale (GSRS), the content of motilin (MOT), the recovery time of gastrointestinal function, SCR and 24h UTP in the observation group were lower than those in the control group (P＜0.05); The satisfaction of patients was higher than that of the control group (P＜0.05); However, there was no significant change in bun, somatostatin (SS) and vasoactive polypeptide (VIP) between the two groups before and after treatment (P＞0.05). Conclusion Acupoint application of Changtong ointment in the treatment of patients with stage 3-5 chronic kidney disease with gastrointestinal complications can effectively reduce the symptoms of gastrointestinal reaction, reduce the level of gastrointestinal hormone and improve the satisfaction of patients. There is no obvious adverse reaction in clinic, so it can be popularized and applied.