Objective To compare the effect of different gonadotropin (Gn) drugs for infertility treatment in polycystic ovary syndrome (PCOS) patients. Methods This retrospective study enrolled a total of 336 patients diagnosed with PCOS and underwent IVF/ICSI treatment from January 2019 to June 2021 in Reproductive Medical Center of West China Second University Hospital of Sichuan University. Based on different Gn drugs used in controlled ovarian stimulation, patients were divided into three groups, rFSH group, uFSH group, and HP-hMG group. All patients adopted the gonadotropinreleasing hormone antagonist protocol. The data regarding baseline characteristics, controlled ovarian stimulation parameters, embryo condition, pregnancy outcome and complications of these groups were collected and analyzed. Results The baseline characteristics were similar in the three groups. Compared with rFSH group and uFSH group, although patients in HP-hMG group retrieved less oocytes and embryos, they had higher oocyte maturation rate and higher quality embryo and lower risk of fresh embryo transplantation cancel rate, and higher clinical pregnancy rate after transplantation. Conclusion For PCOS patients receiving IVF/ICSI treatment, using HP-hMG as exogenous Gn could reduce the follicle development number, improve the oocyte maturation rate and embryo quality, reduce the risk of ovarian hyperstimulation syndrome and fresh embryo transplantation cancel rate.