Objective To investigate the clinical characteristics and effects of long-acting anticoagulant rodenticides (LAARs) poisoning on coagulation function, and establish a risk prediction model for coagulation dysfunction, so as to predict the risk of coagulation dysfunction after LAARs poisoning, and guide clinical diagnosis and treatment. Methods One hundred patients with clinical diagnosis of LAARs intoxication admitted to The Affiliated Hospital of Southwest Medical University from June 2016 and May 2021 were selected, and 96 cases were included after screening by inclusion and exclusion criteria, divided into two groups according to the presence or absence of coagulation dysfunction on admission. The general demographic characteristics, clinical symptoms, laboratory test indexes, and treatment measures of the two groups were compared, and statistically significance or clinically significant variables were selected and further incorporated into a multifactorial logistic regression model to establish a risk prediction model for the development of coagulation dysfunction in patients with LAARs. Results The incubation period of coagulopathy was (8.94±4) 37 days in 96 cases, and the highest number of bleeding symptoms was hematuria in 32 cases. The values of coagulation factors Ⅱ Ⅶ, Ⅸ and Ⅹ in laboratory tests were significantly lower than the reference values. After 3 days of anticoagulation treatment, the values of PT, APTT, TT, fibrinogen (FIB) and INR were decreased to varying degrees, while the value of prothrombin activity (PTA) was increased. Blood coagulation dysfunction group NEU-R%, SCR, CRP, cTNT, PT, APTT, FIB, INR, lost fresh frozen plasma volume indicators such as less high blood coagulation dysfunction group, clotting factor Ⅱ, Ⅶ, Ⅸ, Ⅹ, PTA, Hb value was lower than those of no blood coagulation dysfunction group, the difference was statistically significant (P<0.05). The incubation period after LAARs poisoning is long, and the main clinical symptoms are bleeding in different tissues and organs of the whole body, and hematuria is the most common. Laboratory examination showed that PT and APTT were significantly prolonged and the activities of coagulation factors Ⅱ, Ⅶ, Ⅸ and Ⅹ were decreased. Treatment with vitamin K1 is effective. With five-fold cross-validation study for more than three factor Logistic alternatives of back model, finally selected highest precision model, including type of rat poison, CRP, SCR, NEU-R%, the WBC and VK1 seven variables, such as dosage, medication days Further USES the random forest model for each variable in the model for the importance of the blood coagulation dysfunction risk prediction for sorting, sorting results for CRP> NEU-R %> medication days> the WBC> VK1 dose SCR> type of rat poison (P<0.05). Conclusion The model with the highest prediction accuracy included 7 variables including rat drug type, CRP, SCR, NEU-R%, WBC, dose of VK1 and medication days, among which CRP value was the most important predictor of LAARs poisoning cocoagulant dysfunction risk prediction model.