Objective The influence of sintering temperature on the mechanical properties and microstructure of dental zirconia toughened alumina (zirconia toughened alumina, ZTA) ceramics were analyzed. Methods The dental ZTA ceramics were prepared at different sintering temperatures (1100℃, 1200℃, 1350℃, 1450℃ and 1550℃). The hardness, brittleness and line shrinkage of the ceramics were measured at different sintering temperatures after sintering. The microstructure changes were observed. Results With the increase of sintering temperature, the hardness, brittleness and line shrinkage of ceramics increased gradually, and the hardness, brittleness and line shrinkage of ZTA ceramics were compared at different temperatures, the differences were statistically significant (P<0.05). Conclusion The effects of different sintering temperatures on the brittleness, hardness, line shrinkage and microstructure of ZTA ceramics are different. When the sintering temperature is at 1350℃, the above properties of ZTA ceramics are in the best condition.