Objective To explore the compliance with inhaled glucocorticoid (ICS) in children with asthma in clinical remission stage, and analyze its influencing factors, so as to provide evidencebased basis for improving ICS compliance and disease outcome in children with asthma. Methods From January 2019 to January 2021, 110 children aged between 6 and 14 years with asthma were selected as the research subjects. The parents of the children were surveyed by questionnaire in the outpatient department. The questionnaire included: gender and age of the children, severity of asthma, whether the child′s family has financial difficulties, the education level of the children′s parents, parents′ trust in medical staff, parents′ cognitive level of asthma, mastery of the use of ICS, and parents′ compliance with ICS. Multivariate Logistic regression analysis was used to analyze the influencing factors of compliance. Results Among the subjects, 26.36% had good compliance. The severity of the disease and the proportion of family economic difficulties in the poor compliance group were significantly higher than those in the good compliance group, and the education level, asthma cognition level, mastery of the use of ICS and trust in doctors of the parents were significantly lower than those in the good compliance group, the difference was statistically significant (P<0.05). The results of binary logistics regression analysis showed that the independent risk factors for poor compliance were long course of illness, mild severity of asthma, parents′ education level of primary school or below, family economic difficulties, parents′ poor awareness level of asthma, and parents′ failure to master ICS usage methods (P<0.05). The ROC curve AUC for the joint distribution probability is 0.886 (P<0.05). Conclusion The poor ICS compliance of children with asthma is related to the long course of disease, the severity of asthma, parents′ education, family financial difficulties, parents′ poor awareness of asthma and lack of mastery of ICS use. Individualized intervention should be carried out according to the existing problems in order to improve the ICS compliance of children with asthma and improve the outcome of the disease.