Peyronie's disease (PD) is considered to be a disease in which the connective tissue forms fibrotic plaques after repeated capillary or albuginea injuries in the penis of genetically susceptible individuals. Manifested as penile erectile deformity, erectile dysfunction and penile pain. Because the pathogenesis is not fully understood, the treatment of PD is still a difficult problem. Nonsurgical treatments are mainly used for patients in the early stage of the disease to relieve pain and prevent disease progression, including oral drug treatment, topical treatment, mechanical treatment, etc. In recent years, some new treatment methods have emerged. However, there are little large sample clinical studies accurately evaluating the safety and effectiveness of these treatments. In this review, we provide a overview of the current non-surgical treatments of Peyronie's disease.