Objective To explore the effect of Xuebijing combined with anisodamine on inflammatory factors, immune function and coagulation function in patients with multiple injuries and hemorrhagic shock. Methods 87 patients with multiple injuries and hemorrhagic shock were enrolled in this study between May 2019 and May 2020. Using random number table method, the patients enrolled were divided into control group (42 cases) and observation group (45 cases). The control group was given early fluid resuscitation therapy, and the observation group was treated with Xuebijing combined with anisodamine on this basis. Both groups were given 48h of continuous treatment. The levels of inflammatory factors ［interleukin-6/10 (IL-6/10), and tumor necrosis factor (TNF-α)］, immune function ［CD4+, CD3+, natural killer cells (NK cells), CD4+/CD8+］, and coagulation function ［platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB)］ in the two groups before treatment and after 48h of treatment were comparatively analyzed. The condition of circulatory system and tissue perfusion oxygen metabolism ［mean arterial pressure (MAP), lactate, pH value and central venous oxygen saturation (ScvO2)］ were recorded.Results After 48h of treatment, the levels of IL-6, IL-10 and TNF-α in the two groups decreased (P＜0.05), and the decreases of the observation group were greater than those of the control group (P＜0.05). CD4+, CD3+ and CD4+/CD8+were increased, and the level of NK cells decreased (P＜0.05). There was no statistical difference in MAP between the two groups (P＞0.05). PLT, PT, APTT and TT in the observation group were higher than those in the control group, and FIB was lower than that in the control group (P＜0.05). The pH value and ScvO2 of the observation group were higher than those of the control group, and the lactate level was lower than that in the control group P＜0.0.5). Conclusion Xuebijing combined with anisodamine can improve the effect of early fluid resuscitation in patients with multiple injuries and hemorrhagic shock, improve their coagulation function, reduce the levels of inflammatory factors, and improve immune function.