Objective To explore the effect of thoracic nerve combined with serratus anterior plane block on the quality of early postoperative recovery in patients undergoing pectoralissparing radical mastectomy. Methods The total 117 patients diagnosed with breast cancer and undergoing pectoralsparing radical mastectomy in Handan Central Hospital from September 2020 to March 2021 were selected. According to whether combined thoracic nerve block was performed before surgery, the patients were divided into general anesthesia group and general anesthesia combined nerve block group. The incidence of nausea and vomiting, upper limb paresthesia, axillary pain score and the dosage of analgesic drugs were recorded 24 and 48 h after operation. Fortyeight hours after surgery, 40 quality of recovery scale (QoR40) was performed. The ratio of neutrophil to lymphocyte was compared between preoperative blood routine and one day after operation. Results The incidence of nausea and vomiting and the dosage of analgesic remedial drugs in the general anesthesia combined nerve block group at 24h and 48h were significantly lower than those in the simple general anesthesia group (P＜0.05). At 24h, the upper limbs had abnormal paresthesia and axillary pain. The scores of general anesthesia combined nerve block group were significantly lower than those of simple general anesthesia group (P＜0.05), and the postoperative QoR40 score of general anesthesia combined nerve block group was significantly higher than that of general anesthesia group (P＜0.05). The ratio of neutrophils to lymphocytes after the operation was significantly lower in the general anesthesia combined with nerve block group than in the simple general anesthesia group (P＜0.05). Conclusion General anesthesia combined with thoracic nerve block can improve the comfort and satisfaction of patients after breastmusclesparing radical mastectomy, and help improve the quality of early rehabilitation.