Objective To investigate the effects of lncRNA H19 on proliferation, invasion and EMT of lung cancer SPC-A1 cells and its mechanism. Methods The differential expressions of LncRNA H19, miR-675 and CDH13 in SPC-A1 cells and BEAS-2B cells were detected by real-time quantitative PCR. SPC-A1 cells were transfected with siRNA H19, and the proliferation, invasion and EMT ability of SPC-A1 cells were detected by MTT, Transwell and Western blot assay. The target and correlation between LncRNA H19 and miR-675 were analyzed by miRanda and dual luciferase reporter gene assay. SPC-A1 cells were transfected with miR-675 inhibitor to detect the proliferation, invasion and EMT ability of SPC-A1 cells. The effects of upregulated LncRNA H19 on proliferation, invasion and EMT of SPC-A1 cells via miR-675 were detected. TargetScan and dual luciferase reporter assay were used to analyze the target and correlation between miR-675 and CDH13. SPC-A1 cells were transfected with siRNA CDH13 to detect the proliferation, invasion and EMT ability of SPC-A1 cells. The effect of LncRNA H19 on CDH13 expression through miR-675 was detected by RT-qPCR and Western blot. Results Compared to BEAS-2B cells, the expressions of LncRNA H19 and CDH13 were upregulated （P＜0.01）, the expression of miR-675 was down-regulated （P＜0.01） in SPC-A1 cells. The proliferation, invasion and EMT of SPC-A1 cells were significantly inhibited by siRNA H19 transfection. LncRNA H19 targeted and negatively regulated miR-675. Upregulation of LncRNA H19 through miR-675 or down-regulation of miR-675 expression promoted the malignant development of SPC-A1 cells. miR-675 targeted and negatively regulated CDH13. The proliferation, invasion and EMT of SPC-A1 cells were significantly inhibited by siRNA CDH13 transfection. LncRNA H19 up-regulated the expression of CDH13 by miR-675. Conclusion LncRNA H19 promoted proliferation, invasion and EMT of SPC-A1 cells through spongy miR675 and upregulation of CDH13 expression.