Objective To explore the effects of blood glucose fluctuations on levels of serum homocysteine(Hcy) and blood uric acid(UA) in patients with hypertensive intracerebral hemorrhage(HICH) after minimally invasive aspiration. Methods A retrospective study was performed on the 125 patients with HICH undergoing minimally invasive aspiration in the hospital between January 2018 and October 2020. According to presence or absence of stress hyperglycemia(SHG), they were divided into SHG group(61 cases) and control group(64 cases). Postoperative related parameters between the two groups were compared. Results There was no significant difference in the general data between the two groups(P＞0.05). The preoperative blood glucose in SHG group was higher than that in control group(P＜0.05). The hospitalization time and usage time of antibiotics in SHG group were longer than those in control group(P＜0.05), preoperative hematoma volume was greater than that in control group(P＜0.05), incidence of postoperative pneumonia and mortality within 6 months were higher than those in control group(P＜0.05). There was no significant difference in operation time, incidence of postoperative re-bleeding and intracranial infection between the two groups(P＞0.05). The levels of Hcy and UA in SHG group were higher than those in control group at 1d and 3d after surgery(P＜0.05). Conclusion The postoperative prognosis is worse, recovery time is longer and incidence of complications is higher in HICH patients with SHG than those with normal blood glucose. The levels of serum Hcy and UA are relatively higher in a short time. The perioperative serum indexes should be closely observed to predict change trends of patients’ conditions and take timely preventive measures.