碎裂QRS波与心率变异性及心率减速力对陈旧性心肌梗死的预后评估
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辽宁省科学技术计划项目(20190540935)


The prognostic evaluation of fragmented QRS complex, heart rate variability and heart rate deceleration force on old myocardial infarction
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    摘要:

    目的 探讨碎裂QRS波与心率变异性(HRV)及心率减速力(DC)对陈旧性心肌梗死的预后评估价值。方法 回顾性分析2019年3月~2020年8月辽宁中医药大学附属第二医院收治的115例陈旧性心肌梗死患者的临床资料,根据预后情况分为预后良好组(未出现不良心血管事件,n=72)和预后不良组(出现不良心血管事件,n=43)。对比两组DC、HRV、碎裂QRS波;针对预后不良组死亡情况分为死亡组(n=10)与非死亡组(n=33),经Spearman法分析患者预后情况、死亡率与碎裂QRS波、DC及HRV相关性,对比两组DC、HRV、碎裂QRS波,用ROC曲线分析上述指标预测患者预后情况及死亡情况效能。结果 预后良好组DC、DR8(DC在8个心动周期中连续发生)、DR4(DC在4个心动周期中连续发生)、DR2(DC在2个心动周期中连续发生)、相邻正常R-R间期差值>50 ms的百分比(pNN50)、相邻正常R-R间期差值的均方根(rMSSD)、24 h连续5 min正常R-R间期的标准差(SDANN index)、24 h正常R-R间期的标准差(SDNN)均高于预后不良组(P<0.05),碎裂QRS波阳性率低于预后不良组(P<0.05);非死亡组DC、DR8、DR4、DR2、pNN50、rMSSD、SDANN index、SDNN均高于死亡组(P<0.05)。经Spearman法分析,患者预后情况、死亡率与pNN50、rMSSD、SDANN index、DR8、DR4、DR2、SDNN、DC呈正相关(P<0.05);预后情况与碎裂QRS波阳性率也呈正相关(P<0.05)。经ROC曲线分析,DC、DR2、pNN50、rMSSD、SDANN index、SDNN、DR8、DR4、碎裂QRS波阳性率早期预测预后AUC分别为0.910、0.816、0.995、0.999、0.951、0.998、0.903、0.917、0.747;预测死亡情况的AUC分别为0.970、0.939、0.806、0.994、0.991、0.948、0.871、0.900、0.647。结论 心率减速力、心率变异性、碎裂QRS波在评估陈旧性心肌梗死预后中具有良好预测价值。

    Abstract:

    Objective To explore the prognostic value of fragmented QRS, heart rate variability and heart rate deceleration force in patients with old myocardial infarction. Methods 115 patients with old myocardial infarction analyzed retrospectively were treated in The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from March 2019 to August 2020. According to the prognosis, they were divided into two groups: 72 patients with good prognosis(no adverse cardiovascular events) and 43 patients with poor prognosis(adverse cardiovascular events).The heart rate deceleration force, heart rate variability and fragmented QRS wave of the two groups were compared,ROC curve was used to analyze the efficacy of the above indexes in predicting the prognosis of patients.According to the death of the prognosis group, the patients were divided into two groups: the death group(10 cases) and the non death group(33 cases). After comparing the heart rate deceleration force, heart rate variability and fragmented QRS wave of the two groups. The above indexes were analyzed by ROC curve to predict the death of patients. Results The interval difference of DC, DR8(DC occurring continuously in 8 cardiac cycles), DR4(DC occurring continuously in 4 cardiac cycles), DR2(DC occurring continuously in 2 cardiac cycles) and adjacent normal R-R was>50 in the good prognosis group The percentage of MS(pNN50), root mean square difference of adjacent normal R-R interphase(rMSSD), standard deviation of 24 h consecutive 5 min normal R-R interphase(SDANN index), standard deviation of 24 h normal R-R interphase(SDNN) were higher than those of poor prognosis group(P<0.05). The positive rate of fragmental QRS was lower than that of THE group with poor prognosis(P<0.05). DC, DR8, DR4, DR2, pNN50, rMSSD, SDANN index and SDNN were higher than those in the non-fatal group(P<0.05). Spearman analysis showed that the prognosis and mortality of patients were positively correlated with pNN50, rMSSD, SDANN index, DR8, DR4, DR2, SDNN and DC. The prognosis was also positively correlated with the positive rate of fragmented QRS. After ROC curve analysis, Early prognosis AUC of DC, DR2, pNN50, rMSSD, SDANN index, SDNN, DR8, DR4 and fragmented QRS positive rate were 0.995, 0.999, 0.951, 0.998, 0.910, 0.816, 0.903, 0.917 and 0.747, respectively. The AUC for predicting death was 0.97, 0.939, 0.806, 0.994, 0.991, 0.948, 0.871, 0.900 and 0.647, respectively. Conclusion Heart rate deceleration force, heart rate variability, and fragmented QRS complex have good reference value in evaluating the prognosis of old myocardial infarction.

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  • 在线发布日期: 2022-07-20
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