Objective To establish a rabbit model of VX2 liver cancer and evaluate the imaging features of the tumor by using enhanced CT and digital subtraction angiography(DSA), so as to evaluate the value of CT and angiography in the diagnosis of VX2 liver cancer. Methods Forty New Zealand white rabbits with VX2 liver cancer were implanted by open surgery under direct vision. The tumor growth was evaluated by enhanced CT scan on the 7th and 14th day after the operation. DSA was performed on the 15th day to evaluate the blood supply of the tumor; The rabbits were sacrificed after the angiography, and the gross and microscopic appearance were observed. Results All the 40 New Zealand white rabbits successfully established VX2 liver cancer models. Two weeks after the operation, the tumors could be clearly seen in the liver with CT. Low density lesions could be seen in the liver on plain CT scan, and the edge of the lesions was obviously enhanced on enhanced CT scan in arterial phase, and the enhancement degree decreased in portal venous phase and venous phase; On the DSA, the hepatic artery and its branches were tortuous and thickened, and the tumor staining was obvious, and the tumor and feeding artery presented “ball holding sign”. After HE staining, the tumor showed nestlike or diffuse distribution of tumor cells with obvious nuclear atypia. Conclusion The method of planting tumor tissue of open surgery is a perfect modeling method with high tumor formation rate. Rabbit VX2 hepatoma is a kind of tumor with rich blood supply, which is mainly supplied by hepatic artery. Dynamic contrast-enhanced CT scan can monitor the growth of tumor in real time, which has important value in preoperative and postoperative evaluation. However, DSA has advantages in displaying the blood supply artery of tumor, and DSA can also take into account the role of treatment.