【Abstract】 The tumor microenvironment is the “soil” for tumorigenesis and development. Tumor-associated macrophages are an important part of immune cells in the tumor microenvironment and are an important inflammatory response cell. Highly heterogeneous and highly plastic are macrophages. It can be polarized into different tissue subtypes under different tumor microenvironment conditions. A large number of studies have shown that TAMs play an important role in the occurrence，development and immune regulation of non-melanoma skin cancer. Although the specific pathogenesis of non-melanoma skin cancer is not yet fully understood，the role of TAMs on the occurrence and development of nonmelanoma skin cancer is gradually recognized. This article reviews the occurrence and development mechanisms and targeted therapy of TAMs in common nonmelanoma skin cancers (squamous cell carcinoma of the skin and basal cell carcinoma of the skin) for clinical reference.