【Abstract】 Objective To investigate the feasibility of shear wave elastography (SWE) to evaluate the kidney damage of epidemic hemorrhagic fever patient. MethodsThe young′s modulus values of kidney of epidemic hemorrhagic fever patients and healthy volunteers were compared and analyzed. The ROC curve was plotted and the cut-off value of the area under the curve (AUC) was calculated. Serum creatinine，urinary protein，uric acid and platelet counts were collected and measured within 24 h of Young′s modulus. The correlation between young′s modulus and laboratory indexes was calculated. ResultsThe young′s modulus of renal cortex，medulla and renal sinus increased in patients with epidemic hemorrhagic fever compared with healthy controls. There were statistically significant differences in Young′s modulus between cortex and medulla (P<0.05). When the Emean value of the right renal cortex was 0.820 and the cut-off value was 19.36 kPa，the sensitivity and specificity of the diagnosis of renal damage in epidemic hemorrhagic fever were 70.0% and 89.1%，respectively. When Emax value of left renal cortex was 0.821 and cut-off value was 30.39 kPa，the sensitivity and specificity of the diagnosis of renal damage in epidemic hemorrhagic fever were 70.0% and 84.8% respectively. There was a positive correlation between young′s modulus Emax of left renal cortex and medulla and urinary protein，and between medulla Emean and serum creatinine in epidemic hemorrhagic fever group. The Emax value of young′s modulus in the medulla of the left kidney was negatively correlated with platelet count. ConclusionSWE can be used as a noninvasive quantitative evaluation method for renal damage in epidemic hemorrhagic fever group，Young′s modulus AUC of the right or left renal cortex is large with high sensitivity and specificity，it is recommended to measure Young′s modulus Emean value of the renal cortex in clinical application.