【Abstract】 Objective To explore the predictive value of serum IL-33 and netrin-1 on surgical treatment of patients with aneurysmal subarachnoid hemorrhage (aSAH). Methods226 patients with aSAH were selected as the research objects. According to the 90 day death situation，they were divided into survival group (175 cases) and death group (55 cases). The levels of IL-33 and netrin-1 were compared between the two groups，and the correlation between IL-33 and netrin-1 and the severity of aSAH were analyzed. The clinical value of IL-33 and netrin-1 on the short-term prognosis of patients with aSAH was analyzed by ROC curve，and the influencing factors of short-term prognosis of patients with aSAH were analyzed by logistic regression analysis. ResultsThe level of IL-33 in survival group was lower than that of the death group (P<0.05)，while that of netrin-1 was higher than that of the death group (P<0.05). Serum IL-33 level were positively correlated with Hunt-Hess grades and Fisher grades (P<0.01)，while netrin-1 level were negatively correlated with Hunt-Hess grades and Fisher grades (P<0.01). The logistic regression analysis showed that aneurysm diameter≥5mm，Hunt-Hess grades(Ⅳ~Ⅴ)，Fisher grades (3~4)，elevated serum levels of IL-33 and decreased serum levels of netrin-1 were influence factors for short-term prognosis of aSAH patients. The area under the curve (AUC) of serum IL-33 and netrin-1 in predicting short-term prognosis of aSAH patients were 0.739 and 0.885 respectively. When the cutoff value were 659.46 pg/mL and 223.62pg/mL，the sensitivity were 72.73%、82.61%，and the specificity were 71.20%、81.82%. The AUC of combination of the two indexes was 0.897，the sensitivity was 83.15%，and the specificity was 85.45%. ConclusionSerum IL-33 and netrin-1 are closely related to the short-term prognosis of patients with aSAH，and could be used as markers of short-term prognosis of patients with aSAH，but the predictive value of combination of them is better than that of single application.