【Abstract】 Objective To investigate the effect of reminiscence therapy on cognitive impairment，anxiety，and depression in acute ischemic stroke (AIS) patients. Methods170 patients with AIS diagnosed for the first time were randomly divided into control group and province，China) experimental group according to the ratio of 1：1 by random number method generated by computer，85 cases in each group. The control group was treated with routine treatment，and the experimental group was treated with reminiscence therapy on the basis of the control group，the course of treatment was 1 year. Mini-Mental State Examination (MMSE)，Hospital Anxiety and Depression Scale for anxiety/depression (HADS-A/HADS-D) were assessed at month 0 (M0)，M3，M6，M9，and M12. ResultsDuring the trial，7 patients in the control group were excluded from the trial due to death or other reasons，and 78 patients were finally included in the control group；8 patients in the experimental group were excluded from the trial due to death or other reasons，and 77 patients were included in the experimental group. Experimental group showed higher MMSE score at M6，M9 and M12(P<0.05)，lower cognitive impairment rate by MMSE at M12 compared to control group(P<0.05). As to anxiety，SAS score were lower at M6，M9 and M12 (P<0.05)and anxiety rate by SAS were lower at M9 and M12(P<0.05)，while HADS-A score were lower at M9 and M12 (P<0.05) and anxiety rate by HADS-A were lower at M12 (P<0.05) in experimental group compared with control group. Regarding depression，SDS score were lower at M12 (P<0.05) and HADS-A score were lower at M9 and M12 (P<0.05) in experimental group compared with control group，while depression rate by SDS and HADS-D were was no significant difference(P>0.05). ConclusionReminiscence therapy can reduce cognitive dysfunction，anxiety and depression in AIS patients，suggesting that it has a certain potential in post-stroke management.