Hypertension is an independent risk factor of cardiovascular disease，but the mechanism of target organ injury and cardiovascular disease caused by elevated blood pressure is not very clear. In recent years，the relationship between blood pressure variation (BPV) and cardiovascular disease has attracted more and more attention and become one of the research hotspots. Blood pressure variation contains important information about autonomic nerve regulation of cardiovascular system，which is regarded as an indicator of cardiovascular activity independent of blood pressure and can provide information about blood pressure level，circadian rhythm，and relationship with target organ damage. Therefore，the relationship between blood pressure variation and cardiovascular disease is a topic worthy of study.