Objective To analyze the value of expression of NGF，TrkA and c-Met of patients with primary epithelial ovarian cancer in disease evaluation and prognosis prediction.Methods 115 patients with primary epithelial ovarian cancer treated in Yuechi People′s Hospital from June 2016 to June 2018 were selected as the research objects. All patients were treated with surgery. The tumor tissue and the normal tissue adjacent to the tumor were collected as the cancer tissue group (n=115) and adjacent normal tissue group (n=115). Immunohistochemical method was used to detect NGF，TrkA and c-Met indicators. The expressions of NGF，TrkA，and c-Met in tissues were compared. The correlation between expression of NGF，TrkA and c-Met and the pathological parameters of patients with primary epithelial ovarian cancer was analyzed. The prognosis of patients with primary epithelial ovarian cancer was counted. Kaplan-Meier survival analysis was used to analyze the effect of NGF，TrkA and c-Met expression on the prognostic survival of patients with primary epithelial ovarian cancer. Multivariate Logistic regression was used to analyze the risk factors affecting the prognosis survival of patients with primary epithelial ovarian cancer. ROC was used to analyze the predictive value of NGF，TrkA and c-Met expression for the prognostic survival of patients with primary epithelial ovarian cancer.Results The positive expression rates of NGF，TrkA and c-Met in the cancer tissue group were significantly higher than those in the adjacent normal tissue group，and the difference was statistically significant (P<0.05). The expression of NGF，TrkA and c-Met in patients with primary epithelial ovarian cancer were not significantly correlated with age，type of tissue differentiation，and seroperitoneum (P>0.05). Lymph node metastasis and clinical stage were correlated with the expression of NGF，TrkA and c-Met(P<0.05). 115 patients were followed up for 2 years. The results showed that the 2-year survival rate was 57.39% (66/115). Survival analysis showed that the patients with negative expression of NGF，TrkA and c-Met had a longer survival time than those with positive expression (P<0.05). The degree of tissue differentiation，clinical stage，lymphatic metastasis，NGF，TrkA and c-Met positive are independent risk factors affecting the prognosis survival of patients with primary epithelial ovarian cancer (P<0.05). The ROC curve showed the areas under the NGF，TrkA and c-Met curves and the three combined curves were 0.780，0.851，0.808，0.946，respectively，and the area under the curve of the combined detection was the largest.Conclusion NGF，TrkA and c-Met are closely related to the disease evaluation and prognosis of patients with primary epithelial ovarian cancer，and clinical monitoring of these levels has an important role in the disease evaluation and prognosis of patients.