Objective To analyze the correlation between TIC parameters and various laboratory indexes， and explore the value of contrast-enhanced tic parameters in evaluating the amelioration of renal reperfusion injury during resuscitation from hemorrhagic shock by doxycycline.Methods 24 healthy male SD rats were randomly divided into Sham operation group (Sham group)， hemorrhagic shock reperfusion group (HS-RI group) and doxycycline group (DOX group). The quantitative parameters of time-intensity curve (TIC)， time to Peak (TP)， mean transition time (MTT)， Peak intensity (Peak) and area under curve (AUC) were obtained 24 hours after the modeling. The serum creatinine (Crea) and Urea nitrogen (Urea) levels were detected by venous blood samples after the modeling. Kidney tissues of rats were sacrificed for pathological examination.Results Compared with Sham group， the Peak and AUC values of HS-RI group were increased， TP and MTT were prolonged (P<0.05)， renal tissue damage was obvious， CREA and UREA levels were significantly increased (P<0.05). After doxycycline treatment， Peak and AUC values were decreased， TP and MTT were shortened (P<0.05)， renal tissue damage was improved， and Crea and Urea levels were decreased (P<0.05). TP， MTT， Peak， AUC were significantly positively correlated with Crea， Urea， MMP-2， MMP-9 and TNF-α.Conclusion TIC parameters can provide early and sensitive monitoring of renal cortical perfusion changes before and after drug intervention in fluid resuscitation phase of hemorrhagic shock， and TP， MTT and AUC have some reference values.