康妇炎胶囊联合腹腔镜治疗盆腔粘连合并慢性盆腔痛的疗效
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辽宁省自然科学基金(20180551135)


Efficacy of Kangfuyan Capsule combined with laparoscopy in the treatment of pelvic adhesions with chronic pelvic pain
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    摘要:

    目的 探讨康妇炎胶囊联合腹腔镜治疗盆腔粘连合并慢性盆腔痛的疗效。方法 选取2018年9月~2020年5月我院收治的86例盆腔粘连合并慢性盆腔痛患者的临床资料,根据治疗方式不同分为中西医组(康妇炎胶囊联合腹腔镜治疗,n=46)和对照组(腹腔镜治疗,n=40)。比较两组临床疗效及安全性,采用数字疼痛评分法(NPRS)对比治疗前后疼痛程度,SF-36生活质量评分量表对两组治疗前、治疗1月后生活质量(躯体功能、心理功能、社会功能及精神功能)四个维度进行评估,酶联免疫吸附法测定血清淀粉样蛋白A(SAA)水平,免疫比浊法检测C反应蛋白(CRP)水平,采用自动电化学发光迁移分析仪Cobas e602测定降钙素原(PCT)等炎性因子改善情况。结果 两组治疗前NPRS评分比较差异无统计学意义(P>0.05),治疗后两组NPRS评分均显著下降,且于治疗3月后达到最低值,同时治疗后各时间点中西医组NPRS评分均低于对照组(P<0.05);中西医组临床总有效率显著高于对照组(P<0.05);治疗前两组躯体功能、心理功能、社会功能及精神功能评分比较均无统计学差异(P>0.05),治疗后中西医组躯体功能、心理功能、社会功能及精神功能评分均高于治疗前及对照组(P<0.05);治疗前两组SAA、CRP、PCT水平比较差异均无统计学意义(P>0.05),治疗后中西医组SAA、CRP、PCT水平均低于同组治疗前及对照组(P<0.05);两组并发症及不良反应发生率比较差异无统计学意义(P>0.05)。结论 康妇炎胶囊联合腹腔镜可改善盆腔粘连合并慢性盆腔痛患者疼痛情况,缓解炎症反应,并提高手术疗效及患者生活质量,安全性高,可在临床推广应用。

    Abstract:

    Objective To analyze the efficacy of Kangfuyan Capsule combined with laparoscopy in the treatment of pelvic adhesions with chronic pelvic pain. Methods The clinical data of 86 patients with pelvic adhesions and chronic pelvic pain admitted to our hospital from September 2018 to May 2020 were analyzed. According to the treatment method, they were divided into traditional Chinese and western medicine groups (Kangfuyan capsule combined with laparoscopy treatment, n=46) and Control group ( laparoscopy treatment, n=40). The clinical efficacy and safety between the two groups were compared, and the improvement of pain, quality of life and inflammatory factors before and after treatment were compared. Results There was no statistically significant difference between the two groups of pre-treatment digital pain scoring (NPRS) (P>0.05). After treatment, the NPRS scores of the two groups decreased significantly, and reached the lowest value after treatment for 3 months. At the same time, the NPRS scores of the Chinese and Western medicine group were low at all time points after treatment than those in control group (P<0.05). The total clinical effective rate (97.83%) of the Chinese and Western medicine group was significantly higher than that of the control group (82.50%) (P<0.05). Before treatment, there was no difference in the scores of physical function, psychological function, social function and mental function between the two groups (P>0.05). After treatment, the scores of physical function, mental function, social function and mental function of the traditional Chinese and Western medicine group were higher than those before treatment and the control group (P<0.05). Before treatment, there was no significant difference in serum amyloid A (SAA), immunoturbidimetric method for C-reactive protein (CRP) and procalcitonin (PCT) levels between the two groups (P>0.05). After treatment, the levels of SAA CRP and PCT in the Chinese and Western medicine group were lower than those in the same group before treatment and the control group (P<0.05). There was no difference in the incidence of complications and adverse reactions between the two groups (P>0.05). Conclusion Kangfuyan capsule combined with laparoscopy can improve the pain of patients with pelvic adhesions and chronic pelvic pain, relieve inflammation response,and improve the efficacy of surgery and the quality of life of patients. It is safe and worthy of clinical promotion.

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  • 在线发布日期: 2022-03-23
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