Objective To investigate the relationship between heart failure with preserved ejection fraction (HFpEF) and osteoporosis (OP). Methods According to different ejection fractions, 211 patients with heart failure were divided into three groups: 108 cases of Heart failure with preserved ejection fraction(HFpEF), 52 cases of heart failure with med-range ejection fraction (HFmrEF), 51 cases of heart failure with reduced ejection fraction (HFrEF), and 107 healthy cases in normal control group. The differences of individual factors, vitamin D and incidence of osteoporosis in different types of heart failure between the four groups and the control group were analyzed, and the differences of lumbar bone mineral density and femoral neck bone mineral density in HFpEF group with different ages and genders were further compared. SPSS 23.0 statistical software was used for analysis.Results Compared with the normal control group, OP was common in patients with HF, and OP was more obvious in HFpEF group. Logistic regression analysis showed that HFpEF, age, BMI, vitamin D are risk factors for OP. Among the HFpEF, the decrease of BMD in women and over 70 years old is more obvious, the difference was statistically significant（P＜0.05）. Conclusion Heart failure patients generally have osteoporosis, the HFpEF is more obviously. HFpEF, women, age, BMI, vitamin D are independent risk factors for osteoporosis.