Objective To explore the rehabilitation of patients with acute myocardial infarction (AMI) combined with heart failure (HF) after applying Nucinto and the changes in left ventricular function and structure. Methods From April 2018 to December 2019, 52 patients with AMI and HF in our hospital were selected and received Nuoxinto treatment and regarded as the Nuoxinto group. Another 44 patients received conventional ACEI treatment and regarded as the ACEI group. The efficacy, incidence of adverse reactions, heart function, inflammatory factors of the two groups of patients were compared between the two groups, and the prognosis of the two groups were followed up for one year to compare the prognosis of the two groups. Results The total effective rate of Nuoxinto group (92.31%) was higher than that of ACEI group (P＜0.05). There was no difference in the incidence of adverse reactions (P＞0.05). After treatment, LVEDs, LVEDd, IVST, LVMI and inflammatory factors in Xintuo group were lower than that in ACEI group, while LVEF in Xintuo group was higher than that in ACEI group (P＜0.05). Prognostic follow-up showed that there was no statistical difference in prognostic survival between the two groups (P＞0.05). In the MLHFQ score, the physical activity, emotional state, and other conditions of the Nuoxinto group were better than those of the ACEI group, and the disease recurrence rate was lower than that of the ACEI group (P＜0.05). Conclusion Nuoxinto has a significant effect in the treatment of AMI with HF and has high safety. It can effectively improve the left ventricular function and structure of patients, inhibit the occurrence of inflammatory reactions, improve the prognostic quality of life and reduce the recurrence rate.