Objective To analyze the effects of tripterygium wilfordii polyglycosides combined with beraprost sodium in the treatment of patients with thromboangiitis obliterans on clinical efficacy, visual analogy score (VAS) and inflammatory factors. Methods The clinical data of 70 patients with thromboangiitis obliterans admitted to our hospital from July 2018 to July 2020 were retrospectively analyzed. Finally, 70 patients were enrolled and divided into group A (34 cases, beraprost sodium) and group B (36 cases, tripterygium wilfordii polyglycosides combined with beraprost sodium) according to different drug doses. The clinical efficacy, VAS score, inflammatory factor level, ankle brachial index (ABI), maximum walking distance and adverse reactions were compared between the two groups. Results The total effective rate in group A was 73.53% after treatment, and the total effective rate in group B was 91.67%, which was significantly higher than that in group A (P＜0.05). Numbness, cold sensation and resting pain VAS score, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and immunoglobulin (Ig) in the two groups after treatment were lower than those before treatment, and the above-mentioned VAS score, inflammatory factors TNF-α, IgG and IL-6 levels in group B all were significantly lower than those in group A (P＜0.05). After treatment, the ABI and maximum walking distance, and quality of life of the two groups were significantly higher than those before treatment, and the increase in group B was more significant (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Tripterygium wilfordii polyglycosides combined with beraprost sodium has a definite effect in the treatment of patients with thromboangiitis obliterans. It can effectively relieve pain in patients and inhibit inflammatory reactions in the body without increasing adverse drug reactions and has good safety.