Objective To compare monopolar and laser enucleation (thulium, holmium) of prostate hyperplasia. Methods 693 patients with benign prostate hyperplasia (BPH) who were enrolled and treated in Nanchong Centrqal Hospital from January 2018 to June 2020 were selected as research objects. According to different treatment methods, they were divided into three groups.489 patients underwent holmium enucleation (HoLEP),51 monopolar enucleation,153 patients underwent thulium enucleation (ThuLEP). The operation time, hospital stay, postoperative conditions, postoperative complications and postoperative functional parameters of the three groups were compared. Results Compared with the patients treated by monopolar enucleation, those in the HoLEP and ThuLEP group showed a significantly shorter operation time (P＜0.05), shorter hospital stay (P＜0.05), shorter time of catheterization (P＜0.05). In postoperative complications, compared with the patients treated by monopolar enucleation, those in the HoLEP and ThuLEP group showed a significantly less bleeding (P＜0.05), repeat catheterization (P＜0.05). But there was no significant difference in the volume of the resected prostate, short term stress urinary incontinence, I-PSS, QoL, Qmax, and PVR (P＞0.05). Conclusion HoLEP, monopolar enucleation, and ThuLEP have similar effective in the treatment of benign prostatic hyperplasia. However, HoLEP and ThuLEP can shorten the operation time and hospital stay, reduce postoperative bleeding and the rate of reindwelling catheter, which is safer.