Objective To study the effect of Forsythia suspensa extract on the level of ICAM-1 (intercellular adhesion molecule-1) and inf -γ(interferon gamma) in chronic pelvic inflammatory model rats. Methods 40 SD healthy rats of SPF grade were randomly divided into normal group, model group, positive control group and Forsythia Extract group according to double blind. The model group, positive control group and Forsythia Extract group were used to establish the chronic pelvic inflammatory rat model. After the model was established successfully, the positive control group was given 0.065g/kg norfloxacin capsule, and the Forsythia Extract group was given 250mg / kg The normal group and the model group were not treated. The contents of immunoglobulin, ICAM-1, inf-γ, TLR4, NF-κB, uterine coefficient, hematocrit, plasma viscosity, right uterine mass and swelling degree were measured. Results The content of plasma immunoglobulin and inf-γ water in Forsythia suspense extract group were higher than those in the positive control group, and ICAM-1, TLR4, NF-KB, uterine coefficient, hematocrit, plasma viscosity, uterine quality and swelling degree were lower than those in the positive control group (P＜0.05). Conclusion Forsythia suspensa extract can effectively improve uterine adhesiveness, improve the inflammatory response and abnormal blood flow in rats. Its mechanism may be related to the expression of ICAM-1 and inf-γ in uterine tissue.