Objective To evaluate the efficacy of targeted intervention treatment for patellofemoral pain syndrome (PFPS) according to subgroups.Methods 185 patients with PFPS treated in the sports medicine clinic of Sichuan orthopedic hospital from December 2018 to September 2020 were retrospectively analyzed. They were randomly divided into 90 cases in the routine exercise intervention group (control group) and 95 cases in the typing subgroup (experimental group). The control group was not divided into subgroups, and was uniformly given strength training of knee muscle groups for exercise intervention. The experimental group was divided into subgroups according to 6 clinical tests (group A: 31 cases in strong muscle group, group B: 32 cases in weak muscle strength and muscle tension group, and group C: 32 cases in weak muscle strength and foot pronation group). All treatment cycles were 6 weeks and the frequency was 3 times a week. The VAS score of exercise pain, Kujala patellofemoral score (KPS), dynamic plantar pressure test, isokinetic muscle strength measurement and centripetal relative peak torque of hip and knee flexion and extension were evaluated before and after treatment.Results There were no statistically significant differences in population data and evaluation indexes between the control group and the experimental group. After 6 weeks of intervention, both VAS scores and KPS scores showed good result between control group and the experimental group (P＜0.05). After intervention, the VAS scores and KPS scores of B group showed no statistically significant differences，the VAS scores and KPS scores of other groups were significantly improved compared with those before treatment (P＜0.05). In the experimental groups, the flexion and extension centripetal peak torque values of hip and knee in B and C groups were also significantly increased compared with those before treatment.Conclusion PFPS patients were divided into three groups based on subcomponent types, targeted treatment designed according to subgroup characteristics improves clinical outcomes and reduce the pain degree in patients compared with non-grouped PFPS patients.