Objective Multi-modal electrophysiological monitoring（Neurophysiological monitoring，NM）percutaneous endoscopic cervical discectomy（Percutanous endoscopic cervical discectomy, PECD） was used to analyze its early curative effect. Methods A total of 92 patients with radiculopathy of cervical spondylosis admitted to the Hospital from June 2019 to June 2020 were selected. They were divided into monitoring group (n=46) and non-monitoring group (n=46) according to whether they received NM assistance. The control group was given pure PECD treatment, and the observers were given multimodal neuroelectrophysiological assisted PECD treatment. The two groups of perioperative related indicators, neck and upper limb VAS scores before and after the operation, the patient's nerve function recovery and postoperative complications were observed and compared. Results In terms of perioperative indicators, there was no significant difference in operation time and intraoperative blood loss between the monitoring group and non-monitoring group (P＞0.05), but the hospital stay was significantly shorter than that of the control group (P＜0.05). In terms of postoperative VAS scores, the neck VAS scores and upper limb pain VAS scores of the two groups at 1 month after surgery and at the last follow-up were significantly lower than those before surgery, and the difference was significant (P＜0.05). There was no significant difference between the two groups (P＞0.05). In terms of neurological recovery, the JOA scores of the two groups at 1 month after surgery and at the last follow-up were significantly higher than those before surgery, and the difference was significant (P＜0.05). There was no significant difference between the two groups (P＞0.05). In terms of postoperative complications, the total incidence of patients in the monitoring group was 4.35% and the total incidence of 21.74% in the non-monitoring group was significantly reduced (P＜0.05). Conclusion NM monitoring therapy for PECD patients can help patients recover early, reduce the incidence of postoperative complications, and have a safe and reliable effect.