Objective To evaluate the clinical efficacy and safety of ethanol-injectionon in the treatment for adult SRCs. Methods We included 155 patients (155 cysts) who were diagnosed with SRCs at West China Hospital of Sichuan University From January 2009 to December 2018. Patients were divided into control group (n=31) and observation group (n=124) with a ratio of 4∶1 envelope-randomly. The control group was treated by ultrasound-guided percutaneous fluid aspiration; the observation group was treated by ultrasound-guided percutaneous aspiration combined with ethanol injection and sclerotherapy (UPAES). To compare the efficacy and safety of the two methods, the clinical symptoms, laboratory indices and the change rates of cysts volume of the two groups were compared at four different follow-up times: Within two weeks before treatment (T0), the first day after treatment (T1), three months (T2) and six months (T3) after treatment. Results A total of 148 patients were included in the final analysis. All patients in both groups were free of symptoms before T2. The cure ration in the observation group at T2 and T3 was 79.67%, and 92.68%, respectively, The total efficiency both was 100% at T2 and T3, which was statistically significantly higher than 80% and 60%, of the control group (P＜0.05). No serious complications, liver and kidney function damage were observed in both groups. Conclusion UPAES in the treatment of SRCs has a definite clinical effect and low recurrence rate, less complication,hence has a broad implementation potential in the treatment of these patients.