Objective To investigate the efficacy of sustained release palaripiprone tablets and aripiprazole in the treatment of first episode schizophrenia in young women and their influence on social function. Methods 72 young female patients with first episode schizophrenia admitted in our hospital from May 2017 to February 2019 were randomly divided into two groups, 35 in group A and 37 in group B. Group A was given pariprasidone, group B was given aripiprazole, both groups were treated for 8 weeks.Results At the 4th week, PANSS score of group A was significantly lower （P＜0.05）. There was no significant difference in serum PRL between the two groups at the 4th and 8th week (P＞0.05). At the 8th week of treatment, TG level of lipid metabolism index in both groups was significantly higher (P＜0.05). Glu level in group B was significantly higher (P＜0.05). At the 4th and 8th week, the scores of PSP in group A were significantly higher (P＞0.05). During the treatment, the incidence of weight gain and sedative adverse reactions in group A was significantly higher (P＜0.05). The incidence of insomnia and anxiety in group B was significantly higher (P＜0.05). The total effective rate of group A was significantly higher (P＜0.05). Conclusion Paliperidone and aripiprazole in the treatment of young women with first-episode schizophrenia had no significant effect on serum prolactin, but had a certain impact on lipid metabolism. However, aripiprazole also affected the level of glucose metabolism, causing insomnia, anxiety and other adverse reactions. Paliperidone had a higher social function recovery than aripiprazole, and had a faster onset than aripiprazole. However, after 8 weeks of treatment, the efficacy of paliperidone was similar to that of aripiprazole Adverse reactions such as heavy increase and sedation.