Objective The aim of the study was to evaluate the effect of shikonin on nasal wound healing after mechanical injury in SD rats, which to provide the reference for clinical use of the drug to treat nasal mucosa injury. Methods Nasal mucosa mechanical damage model was prepared. Different doses of Shikonin (1, 2, 4 mg/kg) were given to the treatment groups, at the same time, model control and erythromycin as positive control group were set. The manifestations of rats in each group, and pathological and histopathological changes of nasal mucosa were observed. Results Three different doses of shikonin can improve the clinical performance of rats with nasal mucosal injury, and the difference is statistically significant (P＜0.05); after treatment with different doses of shikonin, the damaged nasal mucosal epithelial cells are repaired, Neutrophils decreased, lymphocyte infiltration decreased, the difference was statistically significant (P＜0.05). Conclusion The three doses of shikonin have a significant improvement effect on the repair of nasal mucosal damage. The effect is related to the dosage and time of the medication. It can be used for clinical prevention and treatment of nasal damage