【Abstract】 Objective To construct a prognostic nomogram prediction model for patients with stage I high-risk endometrial carcinoma (EC) and verify its accuracy.Methods A retrospective analysis was performed on 97 cases of endometrial adenocarcinoma with high-risk factors of stage I treated in Department of Abdominal Oncology, The Affiliated Hospital of Zunyi Medical University from January 1, 2010 to December 31, 2014. Kaplan Meier method was used to calculate the survival rate, Log-rank method was used for univariate analysis, Cox proportional hazard model was used for multivariate analysis. The ROC curve determines the optimal cut off value for hematological parameters to assess the predictive prognosis and correlation with clinical characteristics. The prognostic nomogram was established by the R language software. The consistency index (C-index) and calibration curve(CC) was used to evaluate its accuracy. Results Among 97 EC patients, the metastasis and death of EC occurred in 18 and 11 patients. Histologic grade, LVSI, and adjuvant therapy were independent prognostic factor for OS and DFS. The C-index of newly constructed OS Nomogram prediction model was 0.816, the 3 and 6 year calibration curves showed a good agreement between predicted overall survival. The C-index of DFS Nomogram prediction model was 0.786, and the 3, 6 and 9 year calibration curves showed a good agreement between predicted disease free survival. Conclusion The nomogram can accurately predict the prognosis of postoperative patients with stage I high risk endometrioid adenocarcinoma, which is helpful for clinicians to follow up or provide individualized precise treatment.