Objective To analyze the effects of enalapril combined with valsartan in the treatment of diabetic nephropathy (DN) combined with hypertension on blood pressure and serum inflammatory factors. Methods A total of 123 patients with DN and hypertension who were admitted to the hospital from June 2018 to June 2020 were enrolled as subjects, and they were divided into control group (n=61) and observation group (n=62) by random number method. The group was treated with enalapril, while observation group was treated with enalapril and valsartan. The levels of blood glucose ［fasting blood glucose (FPG), 2h postprandial blood glucose (P2hBG), glycosylated hemoglobin (HbA-1c)］, 24h blood pressure ［systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP)］, renal function ［24h urine protein (24h UPr), creatinine (Scr), blood urea nitrogen (BUN), potassium］ and serum inflammatory factors ［tumor necrosis Factor-α (TNF-α), interleukin-6 (IL6), Creactive protein (CRP)］, and the incidence of adverse reactions were compared between the two groups. Results After treatment, levels of 24h SBP, 24h DBP and 24h MAP in observation group were lower than those in control group (P＜0.05), levels of 24h UPr, Scr and BUN were lower than those in control group (P＜0.05), and levels of TNFα, IL6 and CRP were lower than those in control group (P＜0.05). There were no significant differences in the levels of FPG, P2hBG and HbA-1c, and the incidence of adverse reactions between the two groups (P＞0.05). Conclusion The curative effect of enalapril combined with valsartan is good on DN combined with hypertension, which can reduce levels of blood pressure and serum inflammatory factors, and protect renal function, with high safety.