【Abstract】Objective To compare the value of PET/CT and MR in the diagnosis of marginal recurrence of hepatocellular carcinoma after (HCC) interventional therapy. Methods 62 patients with liver cancer treated in Western Theater General Hospital from October 2015 to December 2019 were followed up by imaging and AFP after 6 months of TACE treatment. PET/CT and MR were performed in each case, and the qualitative diagnosis of marginal lesions was based on the pathological results of puncture as the gold standard. The sensitivity, specificity and accuracy of the two kinds of imaging examination were compared. Results The accuracy and sensitivity of PET/CT group were 919% and 978% respectively, which were significantly higher than those of MR group (790% and 867%) (P＜005). Among them, the AFP level of patients diagnosed in PET/CT group was significantly lower than that of MR group 167±43 ng/ml (P＜005). Conclusion In the followup of liver cancer after TACE treatment, PET/CT has higher sensitivity and accuracy than MR, and can find the focus earlier, which is very beneficial to the prognosis of patients, which is worthy of clinical followup.