【Abstract】Objective This research was to explore the blood gas analysis and serum cardiac function indexes and their relationship with prognosis in patients with congestive heart failure (CHF). Methods The clinical data of 105 patients with CHF admitted to our hospital from December 2017 to December 2019 were retrospectively analyzed. All patients underwent blood gas analysis monitoring before treatment. The serum Nterminal probrain natriuretic peptide (NTproBNP) level was detected. The patients were grouped according to the survival status of patients after 28 d of treatment. The differences in blood gas analysis indexes and serum NproBNP were compared among patients with different survival status before treatment. The correlation between the detection indexes and prognosis was analyzed, and receiver operating characteristic (ROC) curves were drawn to evaluate the efficacy of the detection indexes in evaluating the prognosis of patients. Results There were no significant differences in the arterial partial pressure of oxygen (PaO2) and oxygen deviation between death group and survival group (P＞005). Arterial partial pressure of carbon dioxide (PaCO2) and transcutaneous oxygen partial pressure (TcPO2) in survival group were significantly higher than those in death group (P＜005), while transcutaneous carbon dioxide partial pressure (TcPCO2), carbon dioxide deviation and serum NTproBNP were significantly lower than those in death group (P＜005). TcPO2 and TcPCO2 in patients with CHF were positively correlated with PaO2 and PaCO2 (r=0667, 0988, P＜005), and TcPO2 was negatively correlated with serum NTproBNP (r=-0536, P＜005), and TcPCO2 was positively correlated with serum NTproBNP (r=0524, P＜005). ROC curve analysis showed that the area under the curve, threshold value, diagnostic sensitivity and specificity of carbon dioxide deviation in assessing the prognosis of patients with CHF were 0813, 0467, 77140% and 7524%, and the above values of NTproBNP in assessing the prognosis were 0846, 1946ng/l, 8476% and 8952% respectively, and the sensitivity and specificity of combined diagnosis were 9333% and 9048% respectively. ConclusionIt is necessary to dynamically monitor the blood gas analysis indexes and serum NTproBNP of patients with CHF after admission. Carbon dioxide deviation and serum NTproBNP can be used to evaluate the prognosis of patients with CHF.