【Abstract】Objective In order to reduce the occurrence of seroma after Inguinal scrotal hernia surgery, four clinical methods treating the distal hernia sac were researched. Methods From January 2015 to December 2018, a total of 247 patients with inguinal scrotal hernia were included in the study, and randomly divided into four groups, according to the different distal hernia sacs processing methods. Control group A contained 51 cases, whose distal hernia sacs were not treated. Group B contained 77 cases, whose distal hernia sacs were fenestrated. Group C contained 53 cases, whose remote hernia sacs were internally continuously spirally sutured. Group D contained 66 examples, whose distal hernia sacs were burned. with 2% phenol. Postoperative complications such as seroma were recorded during followup. Results The differences of patients’ age distribution, body mass index, hernia type, and hernia repair methods among the four groups were not statistically significant. The number of patients with testicular atrophy after herniorrhaphy among the four groups was statistically significantly different (P＜005, P=0028). The difference between group B and Group C was statistically significant (P=0020). The difference between group D and Group C was statistically significant (P=0004). The probability of testicular atrophy was higher in group C. Patients’ postoperative pain score at the seventh day, 1 month or 3 month after surgery among four groups were statistically significantly differently (P＜005, P=0003, ＜0001, ＜0001 ). At the seventh day after surgery, the difference between group A and group B was not statistically significant (P=0638). The difference between group C and group D was not statistically significant (P=0891). The difference between the other groups had statistical significance (P＜005, respectively, P=0027, 0028, 0004, 0003). Pain scores in group A or group B were higher than those in group C or group D, and pain in group A or group B were more severe than that in group C or group D. Similarly, in one month or three months after surgery, Pain scores in group A or group B were higher than those in group C or group D, and pain in group A or group B were more severe than that in group C or group D. The number of patients with seroma after herniorrhaphy was compared among the four groups, and the difference was statistically significant (P＜005, P＜0001). The difference between group A and group B was not statistically significant (P=0880). The difference between group C and group D was not statistically significant (P=0909). The difference between the other groups had statistical significance (P＜005, respectively, P=0002, 0003, 0002, 0003). Seroma cases in group A or group B were higher than those in group C or group D. The probability of postoperative seroma in group A or group B was higher than that in group C or group D. Conclusion Compared with distal hernia sacs not being treated, or distal hernia sacs being fenestrated, distal hernia sacs being internally continuously spirally sutured or being burned with 2% phenol can reduce postoperative pain score in postoperative day 7, postoperative 1 month or 3 months, can reduce the occurrence of postoperative seroma, and distal hernia sacs being internally continuously spirally sutured may increased the risk of postoperative testicular atrophy.