【Abstract】Objective To study the evaluation value of cystatin C (Cys C) on the severity and prognosis of hypertriglyceridemic pancreatitis (HLAP).〖WTHZ〗Methods〖WTBZ〗〓The subjects were selected from the Second Affiliated Hospital of Anhui Medical University from January 2017 to December 2019 admitted to the hospital and the time of onset 182 cases of acute pancreatitis in patients with hyperlipidemia type within 24h, the retrospective analysis of its line. According to the severity of the disease, they were divided into 75 cases in the mild group and 107 cases in the medium and severe group. The basic data such as age, gender, body mass index (BMI), white blood cell (WBC), and triglycerides were collected. (Triglyceride, TG), lipase (lipase, LPS), amylase (amylase, AMY), alanine aminotransferase (ALT), glutamic oxalacetic transaminase (AST), cystatin C (Cys C) ), creatinine (Cr) and other laboratory indicators.The differences of the above indicators between the two groups were compared, and the ROC curve was used to evaluate the early prediction and diagnosis ability of Cys C, Cr and Cys C combined with Cr for medium and heavy HLAP.Logistic regression was used to evaluate whether Cys C and Cr are risk factors for the occurrence of moderate to severe HLAP. The occurrence and prognosis of HLAPrelated complications of different levels of Cys C.〖WTHZ〗Results〖WTBZ〗〓The difference in Cys C and Cr between the medium and heavy group and the light group was statistically significant (P＜005). The area under the curve (AUC) of Cys C for early prediction and diagnosis of moderate to severe HLAP was greater than Cr (0720 vs 0.20, P＜005). The combination of Cys C and Cr predicts HLAP severity better than Cys C alone (0732 vs 0720, P＜005).Logistic regression analysis indicated that Cys C≥071 and Cr≥84 were risk factors for the occurrence of moderate to severe HLAP. HLAP patients with Cys C≥071 are more likely to have complications such as multiple organ dysfunction syndrome (MODS), pleural effusion, and lung infection than those with Cys C＜071.〖WTHZ〗Conclusion〖WTBZ〗〓Cys C is better than Cr in predicting the severity of HLAP, and the combined detection is better than the single detection.The level of Cys C can provide a basis for the diagnosis, treatment and prognosis evaluation of hyperlipidemia pancreatitis, and has certain clinical guiding significance.