【Abstract】Objective To investigate features of therapeutic effects of radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) on CT. Methods From January 2018 to January 2020, 53 HCC patients with a total of 65 lesions treated by RFA underwent CT plain scan and triple-phase contrast-enhanced scans before the previous treatments and were followed up after this therapy and the CT data were retrospectively collected. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CT for detecting complete ablation, tumor residual, local tumor progression and new tumor were statistically calculated. Results For showing complete ablation, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CT were 66.7%, 86.4%, 70%, 84.4% and 80%, respectively. For detecting tumor residual, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CT were 54.5%, 85.2%, 42.9%, 90.2% and 80.0%, respectively. For demonstrating local tumor progression within 3 months after RFA, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of followup CT were 57.1%, 88.7%, 40%, 94% and 85%, respectively. For depicting local tumor progression beyond 3 months after RFA, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of CT were 80%, 93.8%, 57.1%, 97.8% and 92.5%, respectively. For demonstrating new tumor in liver within 3 months after RFA, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of follow-up CT were 66.7%, 93%, 57.1%, 95.2% and 89.8%, respectively. For new tumor in liver beyond 3 months after RFA,the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CT were 76.9%, 94.3%, 83.3%, 91.7% and 89.6%, respectively. Conclusion When CT is used to evaluate the efficacy of RFA of HCC, it has a very good effect on the evaluation of local tumor progression and hepatic new tumor after 3 months, it has a good effect on the evaluation of complete ablation and hepatic new tumor within 3 months, and it has a certain value on the evaluation of tumor residual and local tumor progression within 3 months.