【Abstract】Objective To explore the clinical value of oxycodone combined with low-dose nalmefene in preventing remifentanil-induced postoperative hyperalgesia in patients.Methods 184 patients underwent elective gynecologic laparoscopic surgery in the hospital from September 2017 to March 2019 were enrolled. They were divided into control group, oxycodone group, nalmefene group and and combination group by random number table method, 46 cases in each group. Before anesthesia induction, oxycodone group was given oxycodone (0.1 mg/kg), nalmefene group was given nalmefene (0.1μg/kg), combination group was given oxycodone (0.1 mg/kg) and nalmefene (0.1μg/kg) to prevent remifentanil-induced postoperative hyperalgesia, and control group was given the same amount of normal saline. Before skin suture after end of surgery, at 30min, 90min and 180 min after surgery, VAS scoring was performed on patients. The operation time, postoperative awareness recovery time, extubation time, intraoperative drug dosage and postoperative adverse reactions were recorded.Results There was no significant difference in operation time among the four groups (P＞0.05). However, awareness recovery time and extubation time in nalmefene group and combination group were significantly shorter than those in oxycodone group and control group (P＜0.05). At 30min, 90min and 180 min after surgery, VAS scores in combination group were significantly lower than those in nalmefene group, oxycodone group and control group (P＜0.05). There were no significant differences in adverse reactions such as nausea and vomiting, lethargy, dizziness and agitation among the four groups (P＞0.05).Conclusion Oxycodone combined with low-dose nalmefene is conducive to preventing remifentanil-induced postoperative hyperalgesia, shortening extubation and recovery time, without increasing occurrence risk of adverse reactions.