【Abstract】Objective To study curative efficacy of trimetriene and triplinein treatment of endometriosis.Methods 178 patients with endometriosis admitted to our hospital from June 2016 to May 2019 were selected to be included in this study and randomly divided into observation group (n=90) and control group (n=88). The control group was treated with progesterone, and the observation group was treated with tripterylene. The clinical efficacy, luteinizing hormone (LH), estradiol (E2), follicular stimulating hormone (FSH), resistance index (RI), uterine arterial pulse index (PI), vascular endothelial growth factor (VEGF), hypoxia-induced factor (hif-channel) levels, recurrence rate and adverse reactions were compared between the two groups.Results After treatment, the total effective rate of observation group and control group were 96.67% and 85.23%, respectively (P＜0.05). Before treatment, there was no significant difference in the levels of sex hormone indicators between the two groups. After treatment, the levels of LH, E2 and FSH in both groups were significantly reduced, and the observation group was lower than the control group (P＜0.05). Before treatment, there was no significant difference in blood flow parameters between the two groups. After treatment, the blood flow parameters of uterine artery in both groups were significantly reduced, and RI and PI in the observation group were lower than those in the control group (P＜0.05). Before treatment, there was no significant difference in VEGF and HIF- levels between the two groups. After treatment, VEGF and hif-levels in both groups were significantly reduced, and the levels in the observation group were lower than those in the control group (P＜0.05). In the follow-up after treatment, the recurrence rates of the two groups were 2.22% and 11.36%, respectively, with significant difference (P＜0.05). The total incidence of adverse reactions in the two groups was 4.44% and 6.82%, respectively, with no statistically significant difference (P＞0.05).Conclusion Tripterylin is effective in the treatment of endometriosis and can effectively reduce the recurrence rate.