【Abstract】Objective To investigate the clinical application effect of uterine artery infusion chemoembolization (UACE) combined with ultrasound-guided curettage in the treatment of scar pregnancy (CSP). Methods The clinical data of 150 CSP patients admitted from March 2016 to August 2019 were retrospectively analyzed. According to different treatment methods, 107 patients undergoing UACE combined with ultrasound- guided curettage were divided into observation group and 43 patients undergoing curettage after methotrexate (MTX) chemotherapy were divided into control group. The clinical therapeutic effect, curettage operation time, intraoperative and postoperative bleeding volume, postoperative bleeding time, hospitalization time and blood-HCG decrease to normal time were compared between the two groups. Results 105 of 107 patients in the observation group were successful in curettage. The operation time of curettage, the intraoperative bleeding volume, the postoperative bleeding volume, the postoperative bleeding time, the hospitalization time, and the blood-HCG decreased to normal time. all of which were better than those in the control group (P＜0.05). There were no serious complications after embolization in the observation group, of which 2 cases (1.8%) failed curettage, all of which belonged to type Ⅲ CSP, and were treated with laparoscopic pregnancy removal and uterine repair. In the control group, 6 cases (13.9%) failed in curettage. Uterine artery embolization was performed to stop bleeding in emergency due to more bleeding during curettage. The curettage was successful again after operation. Conclusion Uterine artery infusion chemoembolization (UACE) combined with ultrasound-guided curettage in the treatment of scar pregnancy has definite curative effect, less trauma and quick recovery, which can realize the patient's nursing desire and should be popularized as a routine treatment method in clinic.