Objective This study was conducted to determine the value of the circulating TSLP, Bcl-2 and IL-1ɑ in lung adenocarcinoma and explore their correlation with clinicopathological features and clinical significance. 〖WTHZ〗Methods The concentrations of serum TSLP, Bcl-2 and IL-1α were measured using an enzymelinked immunosorbent assay. Results The serum TSLP concentration in patients with lung adenocarcinoma was significantly higher than that in the control group (P＜0.05). Serum TSLP level was higher in patients with advanced stage (stage Ⅱ+stage Ⅲ, stage Ⅳ), tumor diameter ≥3 cm and lymph node metastasis (P＜0.05). The concentration of serum bcl 2 in patients with lung adenocarcinoma was lower than that in control group (P＜0.05). There was no significant difference in serum IL-1α concentration between lung adenocarcinoma group and control group (P＞0.05). There was no correlation among serum TSLP, IL-1α and Bcl-2 levels in patients with lung adenocarcinoma P＞0.05). Serum TSLP level was positively correlated with TNM stage, lymph node metastasis, tumor diameter, CYFRA21-1 and CEA level, and serum bcl-2 concentration was positively correlated with serum CEA level (all P＜0.05).Conclusion TSLP is increased in serum of patients with lung adenocarcinoma, which is related to serum CEA. TSLP has a certain value in the auxiliary diagnosis of lung adenocarcinoma. Serum TSLP is correlated with the development of lung adenocarcinoma. The detection of serum TSLP concentration in patients with lung adenocarcinoma can be used to evaluate tumor progression.