维生素D与老年原发性高血压患者左心功能及Framingham评分的相关性
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国家自然科学基金(81704187);成都中医药大学中医药信息化研究专项(02004901);成都中医药大学附属医院科技发展基金(2017-D-YY-2);首届全国中医药创新骨干人才培训项目


Correlation between vitamin D and left ventricular function and Framingham score in elderly patients with essential hypertension
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    摘要:

    目的 探讨血清维生素D与老年原发性高血压患者左心室功能、Framingham评分及心血管事件危险分层的相关性。方法 选取2018年1月~2019年12月成都中医药大学附属医院心内科门诊及住院部诊治的501例老年原发性高血压患者为研究对象,根据血清维生素D水平分为维生素D充足组(n=144)、维生素D不足组(n=232)及维生素D缺乏组(n=125)。收集患者的高血压病程、吸烟史、血压、体重指数(BMI)、就诊当日的血清胆固醇(TC)、高密度脂蛋白(HDL-C)及空腹血糖(FBG)等。采用经胸心脏彩超评估患者左心室收缩及舒张功能,Framingham 评分(FRS)评估10年心脑血管事件风险评分及危险分层。结果 ①3组中,维生素D不足组女性所占百分率最高;维生素D缺乏组吸烟人数所占百分率、BMI、DBP、SBP、血清TC 及LDL含量最高,HDL浓度最低(均P<0.05)。②3组中,维生素D缺乏组左心室LVEF值最低,左心室质量指数(LVMI)、IVSd、LVDd、LVPW最高,组内E/A比值异常人群百分率最多(P<0.05)。③多元线性回归分析校正年龄、性别、吸烟、血压、血脂及血糖等高危因素后,维生素D仍是IVSd、LVDd、LVPW、LVMI、LVEF及E/A比值的独立危险因素(均P<0.05)。④3组Framingham评分差异:维生素D缺乏组 FRS最高,维生素D不足组次之,维生素D充足组最低(均P<0.05)。⑤3组10年心血管事件危险分层的差异:10年心血管事件评估模型中,维生素D充足组低危人群所占百分率最高,维生素D不足组中危人群所占百分率最高,维生素D缺乏组高危人群所占百分率最高(均P<0.05)。结论 老年原发性高血压患者左心功能随着血清维生素D降低而降低,维生素D缺乏者的10年心血管风险评分及心血管事件危险分层在3组中最高。

    Abstract:

    Objective To investigate the correlation between vitamin D and left ventricular function and Framingham score in elderly patients with essential hypertension. Methods 501 elderly patients with essential hypertension from January 2018 to December 2019 in Department of Cardiology, The Affiliated Hospital of Chengdu University of Traditional Chinese Medicine were selected as the research objects. According to the serum vitamin D level, they were divided into vitamin D sufficient group (n=144), vitamin D insufficient group (n=232) and vitamin D deficiency group (n=125). The course of hypertension, smoking history, blood pressure, body mass index (BMI), serum cholesterol (TC), high density lipoprotein (HDL-C) and fasting blood glucose (FBG) were collected. The left ventricular systolic and diastolic function was evaluated by transthoracic echocardiography. The 10year risk score and risk stratification of cardiovascular and cerebrovascular events were assessed by Framingham score (FRS).Results Among the three groups, the percentage of women in vitamin D deficiency group was the highest. In vitamin D deficiency group, the percentage of smokers, BMI, DBP, SBP, TC and LDL in serum were the highest, while the HDL concentration was the lowest (P<0.05). Among the three groups, the left ventricular LVEF was the lowest, the left ventricular mass index (LVMI), IVSD, LVDD and LVPW were the highest in vitamin D deficiency group, and the percentage of abnormal E/a ratio in the group was the highest (P<0.05). Multiple linear regression analysis showed that vitamin D was still an independent risk factor for IVSD, LVDD, LVPW, LVMI, LVEF and E/a ratio (all P<0.05). FRS was the highest in vitamin D deficiencygroup, followed by vitamin D deficiency group, and lowest in vitamin D sufficient group (P<0.05). In the 10 year cardiovascular event assessment model, the percentage of lowrisk population in vitamin D sufficient group was the highest, that in vitamin D deficiency group was the highest, and that in vitamin D deficiency group was the highest (P<0.05).Conclusion The plasma levels of vitamin D is correlated with left ventricular function in elderly patients with essential hypertension. The 10year cardiovascular risk score and cardiovascular risk stratification in vitamin D deficient group are significantly higher among the three groups.

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  • 在线发布日期: 2021-04-01
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