Objective To study the effect of preoperative noninvasive ventilator ventilation on oxygenation index and recovery quality of patients with sleep apnea syndrome undergoing general anesthesia.Methods 104 patients with obstructivesleep apnea syndrome admitted to our hospital from January 2015 to March 2017 were selected and randomly divided into observation group and control group, with 52 cases in each group. At 5 to 7 d before surgery, control group was given simple nasal catheter oxygen inhalation, and observation group was treated with noninvasive ventilator oxygen inhalation therapy. The two groups were given uvulopalatopharyngoplasty under general anesthesia. Oxygenation indexes were given intraoperative noninvasive monitoring, and the partial pressure of blood oxygen (PaO2) and oxygenation index (OI) before surgery (T0), at 30 min after tracheal intubation (T1), at 1 h after tracheal intubation (T2) and at 30 min after tracheal tube removal (T3), the visual analogue scale (VAS) and Bergman comfort scale (BCS) score at 1, 4, 8, 12, 24 and 48h after surgery, sleep effective rate, sleep latency, apnea hypopnea index (AHI) and microarousal index before and after treatment were recorded. The incidence rates of complications of cough during periextubation, respiratory depression, nausea and vomiting, agitation and lethargy were counted. Results The levels of PaO2at T1, T2and T3in the two groups were significantly higher than those at T0 (P＜0.05). The levels of OI at T1, T2 and T3in the two groups were significantly lower than those at T0(P＜0.05). The levels of PaO2 and OI at T1, T2 and T3 in observation group were higher than those in control group (P＜0.05). At each time point after surgery, the VAS score in observation group was comparable to that in control group (P＞0.05). At 4h, 8h, 12h and 24h after surgery, the BCS score in observation group was higher than that in control group (P＜0.05). The sleep effective rate and sleep latency in observation group after treatment were comparable to those in control group (P＞0.05). The AHI and microarousal index in observation group after treatment were significantly lower than those in control group (P＜0.05). The incidence rate of perioperative complications in observation group was lower than that in control group (9.62% vs 26.92%) (P＜0.05).Conclusion Preoperative noninvasive ventilator oxygen inhalation therapy for patients with sleep apnea syndrome undergoing remifentanil anesthesia can improve the perioperative oxygenation indexes to a certain extent, but it has no obvious effects on anesthesia recovery quality.