Objective To dynamically observe the changes of local bone structure and histology within 2 weeks in the rabbit model of steroidinduced femoral head necrosis and analyze whether the changes are consistent in the superior epiphyseal region, the subepiphyseal region and the lesser trochanter. Methods 45 New Zealand bigeared rabbits were randomly divided into a blank control group (15) and an experimental group (30). After modeling, CT, MRI, micro-CT and histological examination were performed in batches 5, 7, 9, 11 and 13, and the differences of the examination results in the superior epiphyseal region, the subepiphyseal region and the lesser trochanter were analyzed. Results There were no abnormal changes in femoral head on morphology, conventional CT and MRI. Micro-ct showed that trabecular thinning, sparsity, partial fracture and trabecular spacing in the superior epiphyseal region gradually appeared with the extension of modeling time, and the changes on day 9 were statistically significant (P＜0.05), while the changes in the subepiphyseal region and lesser trochanter were not significant. Histological examination showed that with the prolongation of modeling time, fat cells in the superior epiphyseal region increased, bone trabeculae became sparse and partially fractured, empty bone lacunae increased, and blood could be produced in the medullary cavity. The bone trabeculae of the subepiphyseal region and the lesser trochanter were clear and neat, and no lacunae and intramedullary hemorrhage were observed. Conclusion The bone structure of early steroidinduced osteonecrosis of the femoral head in rabbits showed a trend of gradual aggravation, which mainly occurred in the superior epiphyseal area.