【Abstract】Autophagy is a biological process in which pathogens or damaged organelles are transferred to lysosomes for degradation, which is essential for dealing with starvation, oxidative stress and pathogen defense. Neutrophil extracellular traps composed of DNA and histones plays antiinflammatory function by capturing, killing and removing pathogenic microorganisms. Excessive NETs formation might activate immune response to cause tissue damage. The pathological mechanism of NETs was still unclear, but many studies have shown that the vital role of autophagy, NETsmedicated autophagy may be induced through the mTOR signal axis, some autophagy genes, DNA damage responses 1(REDD1) and so on. We aimed to review the mechanism of NETs formation following autophagy, which can provide theoretical basis for revealing clinical disease mechanism and exploring the therapeutic targets.